Skip to Content
MilliporeSigma
  • Whole Grain Consumption Increases Gastrointestinal Content of Sulfate-Conjugated Oxylipins in Pigs - A Multicompartmental Metabolomics Study.

Whole Grain Consumption Increases Gastrointestinal Content of Sulfate-Conjugated Oxylipins in Pigs - A Multicompartmental Metabolomics Study.

Journal of proteome research (2015-07-03)
Anne Krog Ingerslev, Ibrahim Karaman, Murat Bağcıoğlu, Achim Kohler, Peter Kappel Theil, Knud Erik Bach Knudsen, Mette Skou Hedemann
ABSTRACT

The effects of increased intake of dietary fiber as either whole grain rye or as resistant starch compared to a typical low dietary fiber Western-style diet on the metabolomics responses were studied in gastrointestinal content and tissue, peripheral plasma, and urine using a multicompartmental nontargeted liquid chromatography-mass spectrometry (LC-MS) approach in pigs. Both unsupervised and supervised multivariate analyses were used to study differences between the intervention groups, revealing significant effects of the dietary intervention on gastrointestinal contents and urine metabolites. Consumption of a diet composed of whole grain rye flakes and enzyme treated wheat bran increased gastrointestinal content of novel sulfate- and acetic acid-conjugated oxylipins, and urinary secretion of phenolic compounds. Furthermore, potential gastrointestinal and urinary biomarkers for consumption of resistant starch, whole grain rye, and a low dietary fiber intake were detected using multiblock analysis. This study provides insight into microbial fermentation products in the gastrointestinal tract and suggests a potential role in sulfate conjugation of metabolites on the bioavailability of ingested nutrients.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dodecanedioic acid, 99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Hippuric acid, 98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Glycine-1-13C, 99 atom % 13C
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Hyodeoxycholic acid, ≥98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Ursodeoxycholic acid, ≥99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile solution, contains 10.0% acetone, 0.05% formic acid, 40.0% 2-propanol
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile solution, contains 0.05 % (w/v) ammonium formate, 5 % (v/v) water, 0.1 % (v/v) formic acid, suitable for HPLC
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Glycine-1-13C, endotoxin tested, 99 atom % 13C
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile solution, contains 0.1 % (v/v) trifluoroacetic acid, suitable for HPLC
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile solution, contains 0.05 % (v/v) trifluoroacetic acid
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile solution, contains 0.1 % (v/v) formic acid, suitable for HPLC
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
4-Pyridoxic acid, ≥98%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Citric acid, 99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Citric acid, anhydrous, suitable for cell culture, suitable for plant cell culture
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Citric acid, BioUltra, anhydrous, ≥99.5% (T)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Sebacic acid, ≥95.0% (GC)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Perchloric acid, 70%, 99.999% trace metals basis
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Citric acid, ≥99.5%, FCC, FG
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile, anhydrous, 99.8%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Azelaic acid, technical grade, 80%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile, ≥99.5%, ACS reagent
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Hexachloro-2-propanone, produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Enterolactone, ~95% (HPLC)
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Perchloric acid, 0.1 M
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile, for residue analysis, JIS 5000
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile, for chromatography
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Acetonitrile, HPLC Plus, ≥99.9%, poly-coated bottles
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Sebacic acid, 99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Hexachloro-2-propanone, 99%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00
Sigma-Aldrich
Hydroxylamine solution, 50 wt. % in H2O, 99.999%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
100 μg
Estimated to ship on March 22, 2025
A recombinant, preservative-free antibody is available for your target. Try ZRB1515
$484.00