Cell Retention
The growing pressure to increase productivity and reduce manufacturing costs while improving flexibility is driving a renewed interest in perfusion. Perfusion operations deliver high-density cell cultures that alleviate the burden of processing large production bioreactor volumes. Perfusion increases your manufacturing flexibility by delivering higher volumetric productivity and more consistent product quality, with lower capital investments.
Increase your cell density, productivity, and flexibility
Achieve significantly higher viable cell densities while improving your upstream productivity and manufacturing flexibility with the Cellicon® Cell Retention Solution. In combination with your bioreactor, this solution intensifies your upstream by continuously removing spent media and gently retaining high numbers of viable cells. The increased demands of longer-duration perfusion runs are easily met, delivering the high throughput and level of process control you need.
Learn how seed train intensification using the Cellicon® Cell Retention Solution can help you achieve higher cell densities, reducing processing times and number of steps for greater manufacturing flexibility and yields. Find out how easy it is to integrate into your upstream perfusion process.
Key Benefits of Cellicon® Cell Retention Solution
- Enables perfusion processes to achieve higher cell densities
- Reliable and reproducible performance
- High throughput and low fouling
- Comprehensive monitoring and precise control
- Predictable linear scale-up from bench-top to manufacturing scale
- Easy to use and install
The lab-scale Cellicon® Cell Retention Solution consists of the Cellicon® flat sheet single-use filter assembly and controller that are designed to meet your perfused seed train needs. The controller displays an intuitive piping and instrumentation diagram (P&ID) that allows users to instantly visualize all process parameters. This lab-scale solution is ideally suited for your process development, scale-up, and scale-down work.
The process-scale Cellicon® Cell Retention Solution includes the Cellicon® Filter Assembly and the Mobius® Cell Retention System with Bio4C ACE™ control software. Available in 50, 200, 500, 1000, and 2000 L sizes, this easy-to-use solution ensures predictable performance and linear scalability. Bio4C ACE™ control software allows manual processing as well as automated processing via recipes; the software facilitates 21 CFR Part 11 and EudraLex Volume 4 Annex 11 compliance for your clinical and commercial process needs. This solution is easily connected to any bioreactor: all Cellicon® filter assemblies can be welded to any bioreactor bag, and you also have the option to use aseptic connectors.
Related Product Resources
- Data Sheet: Cellicon® Filter and Controller
The benchtop Cellicon™ Perfusion Solution is designed to meet your perfused seed train challenges. It consists of a controller and a flat sheet cell retention filter with a single-use assembly running in tangential flow filtration mode. This easy-to-use solution increases perfusion process efficiency and provides real-time monitoring and control for reliable and consistent performance.
- Data Sheet: Cellicon® Cell Retention Solution for Process Scale
Embark on a journey of discovery as you delve into a wealth of technical insights and specifications, gaining a comprehensive understanding of the product's vast capabilities and unlocking its limitless potential.
- Cell Retention Technology and Specialized Cell Culture Media for Intensified Upstream Processing
This study demonstrates the use of a Cellicon® filter and controller in an N-1 perfusion process with Cellvento® 4CHO-X expansion medium as compared to a control seed train using shake flasks
- Reproducible Scaling of a Cell Retention Filter Using the Cellicon® Cell Retention Solution
This page describes the design attributes of the Cellicon® Filter Assembly and how they simplify process scale-up.
- Operational and Financial Advantages of Cellicon® Cell Retention Solution in an N-1 Perfusion Process
The following study compares the process economics of an N-1 perfusion process at the 2,000 L scale using our Cellicon® Cell Retention Solution versus a commercially available cell retention device
- Performance Guide: Cellicon® Perfusion Solution
Process Recommendations and Scalability Strategies for Optimization of Perfusion Cell Culture with the Cellicon® Cell Retention Solution
- Application Note: Evaluation of Novel Cell Retention Technology and Cell Culture Media for N-1 Perfused Seed Train
This study was designed to evaluate new technologies and explore the benefits of process intensification in an N-1 perfusion application. It used the Cellicon™ perfusion filter and controller, as well as the Cellvento® 4CHO-X Expansion Medium during cell expansion. The products were evaluated based on the metrics of cell growth, viability, titer, nutrient quantities, and product quality.
- Data Sheet: Bio4C ACE™ Control Software
This data sheet outlines the features and benefits of Bio4C ACE™ software.
- White Paper: Upstream Intensification – Enabling Perfusion Processes with Cell Retention Technologies
In this white paper, we explore perfusion processes and how they are becoming a viable solution that can be used to address today’s processing challenges by increasing speed, reducing plant footprint, and improving productivity without compromising product quality.
- White Paper: A Cost Analysis and Evaluation of Perfused Seed Train Scenarios Through Process Modeling
This white paper describes process modeling and comparison of process economics for a conventional upstream process and three perfused seed train alternatives in combination with either a conventional fed-batch bioreactor or high-seed fed-batch bioreactor.
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