902527

Amino-PEG5-t-butyl ester

≥95%

• 別名: tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H₂N-PEG₅-CH₂CH₂COOtBu
• 実験式（ヒル表記法）: C₁₇H₃₅NO₇
• CAS番号: 1446282-18-3
• 分子量: 365.46
• MDL番号: MFCD25424125
• UNSPSCコード: 51171641

特性

• アッセイ: ≥95%
• フォーム: liquid
• 反応適合性: reagent type: cross-linking reagent
• 屈折率: n/D 1.4534
• 密度: 1.4690 g/mL
• 官能基: amine; ester
• 保管温度: −20°C
• SMILES記法: NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): No data available
• 引火点(℃): No data available