902535

Amino-PEG4-t-butyl ester

• 別名: tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H₂N-PEG₄-CH₂CH₂COOtBu, H₂N-dPEG(4)-CO-OtBu
• 実験式（ヒル表記法）: C₁₅H₃₁NO₆
• CAS番号: 581065-95-4
• 分子量: 321.41
• MDL番号: MFCD11041116
• UNSPSCコード: 51171641
• NACRES: NA.22

特性

• 形状: liquid
• 反応適合性: reagent type: cross-linking reagent
• 屈折率: n/D 1.4508
• 密度: 1.04479 g/mL
• 官能基: amine; ester
• 保管温度: −20°C
• SMILES記法: NCCOCCOCCOCCOCCC(OC(C)(C)C)=O
• InChI: 1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
• InChI Key: PKESARRNSGIDRD-UHFFFAOYSA-N

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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その他情報

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法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable