QBD10501

Azido-dPEG^®₄-NHS ester

• 別名: 3-(Azidotetra(ethyleneoxy))propionic acid succinimidyl ester, NHS-Peg4-Azide, Polyethylene glycol
• 実験式（ヒル表記法）: C₁₅H₂₄N₄O₈
• CAS番号: 944251-24-5
• 分子量: 388.37
• MDL番号: MFCD13184948
• UNSPSCコード: 12352108
• PubChem Substance ID: 329823930
• NACRES: NA.22

特性

• アッセイ: >90%
• 形状: solid or viscous liquid
• 反応適合性: reaction type: click chemistry; reagent type: cross-linking reagent; reaction type: click chemistry
• 官能基: NHS ester; azide
• ポリマー構造: shape: linear; functionality: heterobifunctional
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN=[N+]=[N-]
• InChI: 1S/C15H24N4O8/c16-18-17-4-6-24-8-10-26-12-11-25-9-7-23-5-3-15(22)27-19-13(20)1-2-14(19)21/h1-12H2
• InChI Key: OIGKWPIMJCPGGD-UHFFFAOYSA-N

詳細

特徴および利点

The azido-dPEG^®₄-NHS ester contains an azide function on one end of a single molecular weight dPEG^® spacer (17.7 Å) and a reactive group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. NHS ester readily reacts with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

法的情報

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable