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Merck

933899

Sigma-Aldrich

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride

degree of quaternization 50%

別名:

Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan

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About This Item

化学式:
(C12H25N2O5Cl)n(C8H13NO5)m
UNSPSCコード:
12352201
NACRES:
NA.21

詳細

NMR: Conforms to structure

品質水準

形状

(solid, chunks or fiber)

white to off-white

保管温度

2-8°C

詳細

Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications

アプリケーション

Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings

特徴および利点

Water soluble
Cationically modified
Naturally derived and biocompatible

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

933899-BULK:
933899-2G:
933899-VAR:


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Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for
Microbiocidal activity of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride
Chi W, et al.
Journal of Applied Polymer Science, 103, 3851-3856 (2007)
Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Kai Zhao et al.
Vaccines, 9(9) (2021-09-29)
Porcine parvovirus (PPV) is the most important infectious agent causing infertility in pigs, which can be prevented by routine vaccination. Successful vaccination depends on the association with potent adjuvants that can enhance the immunogenicity of antigen and activate the immune

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