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アッセイ
>99% (TLC)
フォーム
powder
包装
pkg of 1 × 5 mg (700121P-5mg)
メーカー/製品名
Avanti Research™ - A Croda Brand 700121P
輸送温度
dry ice
保管温度
−20°C
SMILES記法
O[C@@H]1C[C@H]2[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](C(C)C)CC)C)(CC3)C)CC2)(CC1)C
InChI
1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
InChI Key
LGJMUZUPVCAVPU-HRJGVYIJSA-N
詳細
It is predominantly present in pine oil.
Sitostanol is a 5α-saturated sitosterol derivative.
Sitostanol is a plant stanol and a hydrogenated form of sitosterol.
アプリケーション
Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.
Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).
生物化学的/生理学的作用
Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.
Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.
Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.
包装
5 mL Amber Glass Screw Cap Vial (700121P-5mg)
法的情報
Avanti Research is a trademark of Avanti Polar Lipids, LLC
保管分類コード
11 - Combustible Solids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
700121P-BULK:
700121P-VAR:
700121P-5MG:
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The essential role of cholesterol metabolism in the intracellular survival of Mycobacterium leprae is not coupled to central carbon metabolism and energy production
Journal of Bacteriology, 197(23), 3698-3707 (2015)
2013 IEEE International Conference on Solid Dielectrics (ICSD) IEEE, 131-131 (2006)
Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
The New England Journal of Medicine, 333(20), 1308-1312 (1995)
Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters
The Journal of Nutritional Biochemistry, 19(4), 229-236 (2008)
Lipids, 217-217 (1999)
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