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Merck

840038P

Avanti

12:0 PS

1,2-dilauroyl-sn-glycero-3-phospho-L-serine (sodium salt), powder

別名:

1,2-didodecanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DLPS; PS(12:0/12:0)

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About This Item

実験式(ヒル表記法):
C30H57NO10PNa
CAS番号:
分子量:
645.74
UNSPSCコード:
51191904
NACRES:
NA.25

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 10 mg (840038P-10mg)
pkg of 1 × 200 mg (840038P-200mg)
pkg of 1 × 25 mg (840038P-25mg)

メーカー/製品名

Avanti Research - A Croda Brand 840038P

脂質タイプ

phospholipids

輸送温度

dry ice

保管温度

−20°C

SMILES記法

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O.[Na+]

InChI

1S/C30H58NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-28(32)38-23-26(24-39-42(36,37)40-25-27(31)30(34)35)41-29(33)22-20-18-16-14-12-10-8-6-4-2;/h26-27H,3-25,31H2,1-2H3,(H,34,35)(H,36,37);/q;+1/p-1/t26-,27+;/m1./s1

InChI Key

QBSSGICBQYAHPS-OUPRKWGVSA-M

詳細

Phosphatidylserine (PS), an aminophospholipid is negatively charged and accounts for 2–10% of total cellular lipid. It is located in the membrane leaflets.

アプリケーション

12:0 PS may be used:
  • in the preparation of large unilamellar vesicles (LUVs)
  • as a standard to spike replicas of extracted lipid droplets and calibration curve generation for lipidomic analysis
  • to study its effects on α-secretase activity

生物化学的/生理学的作用

Phosphatidylserine (PS) plays a key role in protein kinase C pathways. It also helps in confining the intracellular proteins to membrane leaflets of cytosol.

包装

5 mL Amber Glass Screw Cap Vial (840038P-10mg)
5 mL Amber Glass Screw Cap Vial (840038P-200mg)
5 mL Amber Glass Screw Cap Vial (840038P-25mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

保管分類コード

11 - Combustible Solids


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

840038P-BULK:
840038P-10MG:
840038P-VAR:
840038P-25MG:
840038P-200MG:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Kristof Schutters et al.
Apoptosis : an international journal on programmed cell death, 15(9), 1072-1082 (2010-05-05)
Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the
Bao Fu Qiao et al.
The journal of physical chemistry. B, 117(17), 5073-5080 (2013-04-10)
Crystalline vesicles are promising nanomaterials due to their mechanical stability in various environments. To control their fabrication, it is essential to understand the effects of different experimental conditions on crystallization. Here we perform atomistic molecular dynamics simulations of anionic lipid
C Preston Moon et al.
Journal of molecular biology, 413(2), 484-494 (2011-09-06)
The free energy of unfolding of a membrane protein from lipids into water (ΔG(o)(w,l)) describes its equilibrium thermodynamic stability. Knowing this parameter gives insight into a membrane protein's sequence-structure-energy relationships. However, there are few measures of membrane protein stability because
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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