860537P

Galactosyl(β) Sphingosine (d18:1)

Avanti Research^™ - A Croda Brand 860537P, powder

• 別名: D-galactosyl-β1-1′-D-erythro-sphingosine
• 実験式（ヒル表記法）: C₂₄H₄₇NO₇
• CAS番号: 2238-90-6
• 分子量: 461.63
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• 形状: powder
• 包装: pkg of 1 × 25 mg (860537P-25mg); pkg of 1 × 5 mg (860537P-5mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 860537P
• 脂質タイプ: sphingolipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
• InChI: 1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21-,22-,23+,24+/m0/s1
• InChI Key: HHJTWTPUPVQKNA-PIIMIWFASA-N

詳細

詳細

Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.

アプリケーション

Galactosyl(β) Sphingosine (d18:1) has been used in the liposome preparation for α-synuclein aggregation studies. It is suitable for use to test its inhibitory effect on cytokinesis in cells expressing T-cell death-associated gene 8 (TDAG8). It is also suitable for use as a standard for differential mobility spectrometry (DMS) coupled with liquid chromatography in electrospray ionizatoin tandem mass spectrometry (LC-ESI-DMS-MS/MS) for ceramide quantification and ultra-high resolution ion mobility spectrometry measurments.

生物化学的／生理学的作用

Galatosylsphingosine or psychosine is a cytotoxic lipid which accumulates in oligodendrocytes due to dysfunctional lysosomal enzyme galactosylceramidase and is implicated in globoid cell leukodystrophy. Psychosine accumulation induces demyelination, astrocyte dysfunction and pro-inflammatory cytokine release in Krabbe disease.

包装

5 mL Amber Glass Screw Cap Vial (860537P-25mg)

5 mL Amber Glass Screw Cap Vial (860537P-5mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable