1.00590

グリシン

crystalline, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• 別名: アミノエタン酸, アミノ酢酸, グリココール
• 化学式: NH₂CH₂COOH
• CAS番号: 56-40-6
• 分子量: 75.07
• Beilstein: 635782
• MDL番号: MFCD00008131
• UNSPSCコード: 12352121
• EC Index Number: 200-272-2

特性

• 認証: BP; ChP; JP; Ph. Eur.; USP
• 品質水準: 500
• 蒸気圧: 0.0000171 Pa ( 25 °C)
• 詳細: EMPROVE^® EXPERT Ph Eur,BP,JP,USP
• 製品種目: EMPROVE^® EXPERT
• アッセイ: 98.5-101.0% (calculated on dried substance, perchloric acid titration)
• フォーム: crystalline; solid
• テクニック: inhibition assay: suitable
• pH: 5.9-6.4 (20 °C, 50 g/L in H₂O)
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• 溶解性: soluble 250 g/L
• 密度: 1.161 g/cm³ at 20 °C
• アプリケーション: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 保管温度: 2-30°C
• SMILES記法: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI Key: DHMQDGOQFOQNFH-UHFFFAOYSA-N

詳細

詳細

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Glycine is an amino acid which is used widely in the biopharma industry as stabilizer, tonicity modifier, buffer and precipitating agent. It is also used as an emollient, emulsifying agent and solubilizer in solid and semi-solid formulations.
Due to its low microbial and endotoxin limits, Glycine cryst. Emprove^® Expert is especially suitable for high-risk applications.

生物化学的／生理学的作用

脊髄における抑制性神経伝達物質であり、NMDAレセプターのアロステリック調節因子です。

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

The substance 1.00590 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable