おすすめの製品
由来生物
human
品質水準
リコンビナント
expressed in E. coli
分子量
Mw 100 kDa
メーカー／製品名
Upstate®
テクニック
activity assay: suitable (histone acetyltransferase (HAT))
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
遺伝子情報
human ... EP300(2033)
詳細
Product Source: Expressed in E. coli.
アプリケーション
Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.
品質
Routinely evaluated by HAT Assay.
単位の定義
Specific Activity: 1 Unit is defined as the transfer of 1nmol of [3H]-acetate/minute to acid-extracted histones.
保管および安定性
-20°C for up to 6 months from the date of receipt.
その他情報
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
14-418:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.
Weibin Wang,Kewu Pan,Yifan Chen,Chunyin Huang,Xiaowei Zhang
Nucleic Acids Research null
A Giordano et al.
Journal of cellular physiology, 181(2), 218-230 (1999-09-25)
p300 and CBP are highly related nuclear proteins, which have been implicated in transcriptional responses to disparate extracellular and intracellular signals. There are at least two very good reasons for which p300 and CBP have attracted the attention of the
R L Schiltz et al.
The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates
Dennis Shin-Shian Hsu et al.
Cancer cell, 26(4), 534-548 (2014-10-15)
Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein
Junhui Xue et al.
Cancer letters, 471, 12-26 (2019-12-08)
Alpha-fetoprotein (AFP) is a well-established biomarker for hepatocellular carcinoma (HCC). Here, we investigated the acetylation state of AFP in vivo. AFP acetylation was regulated by the acetyltransferase CBP and the deacetylase SIRT1. Acetylation of AFP at lysines 194, 211, and
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