189480-M

Autocamtide-2 Related Inhibitory Peptide

The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Autocamtide-2 Related Inhibitory Peptide, AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
• 実験式（ヒル表記法）: C₆₄H₁₁₆N₂₂O₁₉
• 分子量: 1497.74
• UNSPSCコード: 12352202

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: water: 1 mg/mL
• 保管温度: −20°C

詳細

詳細

Non-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC₅₀ = 40 nM) and is 50 and 500 times more potent than Ala²⁸⁶-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.

Non-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC₅₀ = 40 nM). It is about 50 times more potent than [Ala²⁸⁶]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca²⁺-induced insulin secretion from electropermeabilized islets.

生物化学的／生理学的作用

Target IC₅₀: 40 nM against calmodulin-dependent protein kinase II

警告

Toxicity: Standard Handling (A)

シーケンス

H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH

その他情報

Bhat, H.S., et al. 2000. Biochem. Pharmacol.60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable