250401

Ciliobrevin D

≥99% (HPLC), powder, cytoplasmic dynein inhibitor, Calbiochem^®

• 別名: Cytoplasmic Dynein Inhibitor, Ciliobrevin D, 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor
• 実験式（ヒル表記法）: C₁₇H₈Cl₃N₃O₂
• CAS番号: 1370554-01-0
• 分子量: 392.62
• MDL番号: MFCD32671853
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Cytoplasmic Dynein Inhibitor, Ciliobrevin D, Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange
• 溶解性: DMSO: 2.5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: O=C(C1=CC=C(Cl)C=C1N/2)NC2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)/C#N
• InChI Key: JKKSCGHDRHRWOQ-FOWTUZBSSA-N

詳細

詳細

A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 µM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable