317642

Dipeptidylpeptidase IV Inhibitor IV, K579

The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: Dipeptidylpeptidase IV Inhibitor IV, K579, (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
• 実験式（ヒル表記法）: C₁₇H₂₄N₆O
• CAS番号: 440100-64-1
• 分子量: 328.41
• MDL番号: MFCD07364044
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white to light brown
• 溶解性: 1 M HCl: 16 mg/mL; DMSO: 32 mg/mL; ethanol: 6.5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: N3([C@@H](CCC3)C#N)C(=O)CNC1(CCN(CC1)c2ncccn2)C
• InChI: 1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
• InChI Key: JERPHRNGJBSFAP-AWEZNQCLSA-N

詳細

詳細

A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC₅₀ = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable