324411

Dynamin Inhibitor II, MiTMAB

The Dynamin Inhibitor II, MiTMAB, also referenced under CAS 1119-97-7, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

• 別名: Dynamin Inhibitor II, MiTMAB, Tetradecyl trimethyl ammonium Bromide, Myr istyl tri methyl ammonium Bromide, TTAB
• 実験式（ヒル表記法）: C₁₇H₃₈BrN
• CAS番号: 1119-97-7
• 分子量: 336.39
• MDL番号: MFCD00011770
• UNSPSCコード: 41121801
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥99% (titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: DMSO: 10 mg/mL; water: 100 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [Br-].[N+](CCCCCCCCCCCCCC)(C)(C)C
• InChI: 1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
• InChI Key: CXRFDZFCGOPDTD-UHFFFAOYSA-M

詳細

詳細

A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC₅₀ = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP.

包装

Packaged under inert gas

警告

Toxicity: Corrosive (L)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Quan, A., et al. 2007. Mol. Pharmacol.72, 1425.
Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett.14, 3275.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS05,GHS07,GHS09
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H318,H335,H373,H410
• 注意書き: P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P314
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 3
• ターゲットの組織: Gastrointestinal tract, Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable