400010

Caspase-1 Inhibitor I

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: Caspase-1 Inhibitor I, IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
• 実験式（ヒル表記法）: C₂₃H₃₂N₄O₈
• CAS番号: 143313-51-3
• 分子量: 492.52
• MDL番号: MFCD00237123
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 5 mg/mL; water: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: N([C@@H](CC(=O)O)C=O)[C@@H](C)C(=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)Cc1ccc(cc1)O)C(C)C
• InChI: 1S/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1
• InChI Key: KQCBPHUOVBKBPQ-SJVNDZIOSA-N

詳細

詳細

A potent, specific, and reversible inhibitor of caspase-1 (K_i = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (K_i = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
caspase-1, human recombinant

Product does not compete with ATP.

Reversible: yes

Target K_i: 200 pM for human recombinant caspase-1

警告

Toxicity: Standard Handling (A)

シーケンス

Ac-Tyr-Val-Ala-Asp-CHO

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature375, 81.
Walker, N.P.C., et al. 1994. Cell78, 343.
Wilson, K.P., et al. 1994. Nature370, 270.
Thornberry, N.A., et al. 1992. Nature356, 768.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable