5.05227

(-)-Cytisine

• 別名: (-)-Cytisine, nAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
• 実験式（ヒル表記法）: C₁₁H₁₄N₂O
• CAS番号: 485-35-8
• 分子量: 190.24
• MDL番号: MFCD00136048
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: pale yellow
• 溶解性: water: 100 mM
• 保管温度: 2-8°C
• SMILES記法: N21C[C@@H]3CNC[C@H](C3)C2=CC=CC1=O
• InChI: 1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9-/m0/s1
• InChI Key: ANJTVLIZGCUXLD-IUCAKERBSA-N

詳細

詳細

A potent agonist selective for neuronal nAChRs (K_i = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.

生物化学的／生理学的作用

Primary Target
nAChR

Reversible: yes

Target K_i: 2, 5890, 480, 329, and 492 nM at &alpha

警告

Toxicity: Toxic (F)

再構成

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

その他情報

Chen, Y., et al., 2012. Br J Pharmacol.165, 1006.
West, R., 2011, N. Engl. J. Med.365, 1193.

Happe, K., et al., 1994. Neurosci.62, 929.

Reavill, C. et al., 1990. Neuropharmacol.29, 619.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301 + H311 + H331
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable