513024-M

PD 151746

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.

• 別名: PD 151746, 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
• 実験式（ヒル表記法）: C₁₁H₈FNO₂
• CAS番号: 179461-52-0
• 分子量: 205.19
• MDL番号: MFCD03453564
• UNSPSCコード: 12352200

特性

• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange
• 溶解性: DMSO: 200 mg/mL; methanol: 5 mg/mL
• 保管温度: −20°C
• InChI: 1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
• InChI Key: HWMQHECFXSVZGN-KMKOMSMNSA-N

詳細

詳細

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for µ-calpain (Calpain I) over m-calpain (Calpain II) (K_i values, 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide induced apoptosis.

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (K_i values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.

生物化学的／生理学的作用

Primary Target
calpain-1

Target K_i: 260 nM against calpain-1

警告

Toxicity: Standard Handling (A)

再構成

Unstable in solution; reconstitute just prior to use.

その他情報

Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable