565780

β-Secretase Inhibitor III

The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: β-Secretase Inhibitor III, Inhibitor GL189, H-EVNstatineVAEF-NH₂
• 実験式（ヒル表記法）: C₄₄H₇₀N₁₀O₁₄
• 分子量: 963.09
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 溶解性: DMSO: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.

A substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.

生物化学的／生理学的作用

Cell permeable: no

Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells

Primary Target
BACE

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

H-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Capell, A., et al. 2002. J. Biol. Chem.277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem.45, 259.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable