S4562

β-Secretase inhibitor

≥97% (HPLC), powder

• 実験式（ヒル表記法）: C₇₃H₁₁₈N₁₆O₂₇
• 分子量: 1651.81
• MDL番号: MFCD02683580
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• 分子量: ~_1.65 kDa
• 色: white
• mp: 200 °C
• 溶解性: DMSO: soluble
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: N([C@H]([C@@H](O)CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CC(C)C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@H](O)C)CCC(=O)O)C
• InChI: 1S/C73H118N16O27/c1-11-37(8)59(88-66(108)45(23-27-56(101)102)79-63(105)43(21-25-54(97)98)81-72(114)60(39(10)91)89-62(104)41(75)19-15-16-28-74)71(113)85-49(33-90)68(110)80-44(22-26-55(99)100)65(107)87-58(36(6)7)70(112)83-47(31-51(76)93)67(109)82-46(29-34(2
• InChI Key: CQTBDEGWLSDJEP-JMAXQNTPSA-N

詳細

Amino Acid Sequence

Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe

詳細

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1), an aspartic protease belongs to the protease family of enzymes comprises of six luminal cysteine residues. These residues help in the formation of three intermolecular disulfide bonds and N-linked glycosylation sites.

アプリケーション

β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay.(2)

β-Secretase inhibitor may be used to inhibit BACE1 in studies related to AD.

生物化学的／生理学的作用

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is a β-secretase that initiates the production of amyloid protein in Alzheimer′s dieases (AD) patients. β-Secretase inhibitors decrease the generation of β amyloid and formation of amyloid plaques typical of AD.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)