565851

NSC-87877

≥97% (HPLC), solid, SHP1/2 PTPase inhibitor, Calbiochem^®

• 別名: SHP1/2 PTPase Inhibitor, NSC-87877, 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
• 実験式（ヒル表記法）: C₁₉H₁₁N₃Na₂O₇S₂
• CAS番号: 56932-43-5
• 分子量: 503.42
• UNSPSCコード: 12352200
• NACRES: NA.54

特性

• product name: SHP1/2 PTPase Inhibitor, NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: red-brown
• 溶解性: water: 10 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;
• InChI Key: YOGRUDWAJPVHEL-LLDDCTHSSA-L

詳細

詳細

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC₅₀ = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
SHP1/2 PTPase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Chen, L., et al. 2006. Mol. Pharmacol.70, 562.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable