682162

Xestospongin D, Xestospongia sp.

A reversible, membrane-permeable blocker of IP3-mediated Ca²⁺ release (IC₅₀ = 648 nM).

• 別名: Xestospongin D, Xestospongia sp., XeD
• 実験式（ヒル表記法）: C₂₈H₅₀N₂O₃
• 分子量: 462.71
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥90% (TLC)
• フォーム: film
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: clear
• 溶解性: ethanol: 1 mg/mL; methanol: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A membrane-permeable, reversible blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).

A reversible, membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
IP3-mediated Ca2+

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 648 nM in blocking IP3-mediated Ca2+ release

警告

Toxicity: Harmful (C)

調製ノート

Sonication may be required to achieve complete solubilization.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable