8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

• 別名: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
• 実験式（ヒル表記法）: C₈H₁₇N₃ · xHCl
• CAS番号: 25952-53-8
• 分子量: 155.24 (free base basis)
• MDL番号: MFCD00012503
• UNSPSCコード: 12352107
• EC Index Number: 247-361-2
• NACRES: NA.22

特性

• 製品名: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
• 品質水準: 200
• フォーム: solid
• 反応適合性: reaction type: Coupling Reactions
• mp: 110-115 °C
• アプリケーション: peptide synthesis
• 保管温度: −20°C (−15°C to −25°C)
• SMILES記法: Cl.N(CCCN(CC)C#N)(C)C
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• InChI Key: FDXPUDRRFDHONO-UHFFFAOYSA-N

詳細

詳細

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

アプリケーション

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:

• A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
• A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
• A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

安全性情報

• ピクトグラム: GHS06,GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H302 - H311 - H315 - H317 - H373 - H410
• 注意書き: P260 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P314
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable