8.52101

Fmoc-Arg(Boc)₂-OH

Novabiochem^®

• 別名: Fmoc-Arg(Boc)₂-OH, N-α-Fmoc-N-ω,N-ωÆ-bis-t-butoxycarbonyl-L-arginine
• 実験式（ヒル表記法）: C₃₁H₄₀N₄O₈
• CAS番号: 143824-77-5
• 分子量: 596.67
• MDL番号: MFCD27957351
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• 品質水準: 200
• 製品種目: Novabiochem^®
• アッセイ: ≥90.0% (acidimetric); ≥91.0% (HPLC); ≥95% (TLC)
• フォーム: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 官能基: Boc; Fmoc
• 保管温度: 15-25°C
• SMILES記法: N([C@@H](CCCN\C(=N\C(=O)OC(C)(C)C)\NC(=O)OC(C)(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C31H40N4O8/c1-30(2,3)42-28(39)34-26(35-29(40)43-31(4,5)6)32-17-11-16-24(25(36)37)33-27(38)41-18-23-21-14-9-7-12-19(21)20-13-8-10-15-22(20)23/h7-10,12-15,23-24H,11,16-18H2,1-6H3,(H,33,38)(H,36,37)(H2,32,34,35,39,40)/t24-/m0/s1
• InChI Key: WPAALELGEWGQEG-DEOSSOPVSA-N

詳細

詳細

An excellent derivative for Fmoc SPPS of Arg-containing peptides ^[1]. Coupling of this derivative can be effected using standard activation methods, such as PyBOP^® or TBTU, although longer reaction times may be necessary due to the bulkiness of the side-chain protection.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] A. S. Verdini, et al. (1992) Tetrahedron Lett., 33, 6541.

関連事項

Replaces: 04-12-1249

アナリシスノート

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 98.5 % (a/a)
Purity (TLC(011A)): ≥ 95 %
Assay (HPLC, area%): ≥ 91.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.5 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable