PHR1185

ベジル酸アムロジピン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 2-[(2-アミノエトキシ)-メチル]-4-(2-クロロフェニル)-1,4-ジヒドロ-6-メチル-3,5-ピリジンジカルボン酸 3-エチル 5-メチルエステル ベンゼンスルホン酸塩, ノルバスク
• 実験式（ヒル表記法）: C₂₀H₂₅ClN₂O₅ · C₆H₅SO₃H
• CAS番号: 111470-99-6
• 分子量: 567.05
• MDL番号: MFCD00887594
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823196
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. Y0000049; traceable to USP 1029501
• APIファミリー: amlodipine
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
• InChI: 1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
• InChI Key: ZPBWCRDSRKPIDG-UHFFFAOYSA-N
• 遺伝子情報: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amlodipine besylate is a calcium channel blocker, which inhibits the trans membrane influx of calcium ions into vascular smooth muscles and cardiac muscle. It belongs to the dihydropyridine family. It is used in combination with atorvastatin calcium to treat vasospastic angina, chronic stable angina, hypertension, in elevated serum triglyceride levels, primary dysbetalipoproteinemia.

アプリケーション

Amlodipine besylate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

アムロジピンは、L型カルシウムチャネルのブロッカ-です。アムロジピンは心臓血管薬に分類されており、Ca_V1あるいはL型の電位依存性カルシウムチャネルに作用します。また、アムロジピンには血圧降下作用や抗狭心作用があります。主として活性があるのは(-)-異性体です。アムロジピンはヒト類表皮癌由来A431細胞の増殖を阻害するとともに、雄性ラットで生殖機能を抑制する作用があります。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0717 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3