PHR1854

カンデサルタンシレキセチル

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 2-エトキシ-1-[[2'-(2H-テトラゾール-5-イル)[1,1'-ビフェニル]-4-イル]メチル]-1H-ベンズイミダゾール-7-カルボン酸1-[[(シクロヘキシルオキシ)カルボニル]オキシ]エチルエステル, TCV 116, TCY 116
• 実験式（ヒル表記法）: C₃₃H₃₄N₆O₆
• CAS番号: 145040-37-5
• 分子量: 610.66
• MDL番号: MFCD00871371
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. Y0001388; traceable to USP 1087803
• APIファミリー: candesartan
• フォーム: powder
• 包装: pkg of 200 mg
• アプリケーション: pharmaceutical
• SMILES記法: CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6
• InChI: 1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
• InChI Key: GHOSNRCGJFBJIB-UHFFFAOYSA-N
• 遺伝子情報: human ... AGTR1(185)

詳細

詳細

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Candesartan cilexetil is an angiotensin II receptor antagonist used as a prodrug in the treatment of hypertension.

アプリケーション

This pharmaceutical secondary standard can also be used as follows:

• Determination of candesartan cilexetil in tablet formulations by a UV/fluorescence spectrophotometric method
• Study of the release of candesartan cilexetil in tablet form by reversed-phase high-performance liquid chromatography (RP-HPLC)
• Simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in pharmaceutical preparations using liquid chromatography in combination with photodiode array detector (DAD) and evaporative light scattering detector (ELSD)
• Spectroflourimetric determination of four angiotensin II receptor antagonists (AIIRA’s) in their pure form as well as pharmaceutical formulations

生物化学的／生理学的作用

カンデサルタンシレキセチルは、強力なアンジオテンシンII受容体アンタゴニストであるカンデサルタンのプロドラッグです。プロドラッグは腸内のエステラーゼにより切断され、活性分子を遊離します。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

脚注

To see an example of a Certificate of Analysis for this material enter LRAB8504 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H360D,H373
• 注意書き: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Repr. 1B - STOT RE 2 Oral
• ターゲットの組織: Kidney,Blood
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable