A268

抗A₁アデノシンレセプター抗体 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• MDL番号: MFCD02660703
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IHC (f); IP; WB
• クローン: polyclonal
• 化学種の反応性: human, rat, bovine (weak)
• citations: 11
• テクニック: immunohistochemistry (frozen sections): 1:100; immunoprecipitation (IP): suitable; western blot: 1:1,000

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 36-40 kDa
• 化学種の反応性: human, rat, bovine (weak)
• テクニック: immunohistochemistry (frozen sections): 1:100; immunoprecipitation (IP): suitable; western blot: 1:1,000
• UniProtアクセッション番号: P30542
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ADORA1(134) ; rat ... Adora1(29290)

詳細

詳細

ADORA1 is an adenosine receptor which is part of the G-protein coupled receptor family of proteins. ADORA1 functions as a receptor for adenosine to regulate vasodilation and vasoconstriction in cardiac tissue and kidneys.

Adenosine receptors (ARs) are members of the 7-transmembrane domain G protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of Ars ubiquitously mediates cell signalling pathways that protect tissues and organs from damage . Additionally, Ars modulate immune functions of the brain and alters the neurotransmission by glutamatergic and dopaminergic systems
The A1AR is a glycoprotein of MW 36-40 kDa that can activate Gi and Go proteins in vitro In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of K⁺ channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system
A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release In white adipocytes, A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis

Anti-A1 Adenosine Receptor is specific for A1 adenosine receptor adenosine receptor subunit. By immunoblotting, it reacts strongly with human and rat, and weakly with bovine A1. The antibody detects A1 adenosine receptor in human hippocampus by immunohistology and may be used for immunoprecipitation and confocal microscopy

免疫原

ラットA₁アデノシンレセプタ-のC末端ドメインのアミノ酸309-326に由来する合成ペプチド(Gln-Pro-Lys-Pro-Pro-Ile-Asp-Glu-Asp-Leu-Pro-Glu-Glu-Lys-Ala-Lys-Ala-Glu-Asp)。

アプリケーション

Rabbit anti-A1 adenosine receptor antibody can be used for immunohistochemistry and immunoblotting assays using rat tissues. The antibody can also be used for immunocytochemistry assays using rat spinal cord tissues. The product may also be used for immunoprecipitation applications.

物理的形状

PBS溶液 (1mg/mL BSA, 0.05%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)