B7185

Anti-Breast Cancer Resistance Protein antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-BCRP
• MDL番号: MFCD03791618
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~70 kDa
• 化学種の反応性: mouse, human
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 20-40 μg/mL using heat-retrieved tissue sections from human term placenta by indirect immunoperoxidase staining of syncytiotrophoblasts.; western blot: 2.5-5 μg/mL using whole extract of human term placenta or mouse kidney and a chemiluminescent detection reagent
• UniProtアクセッション番号: Q9UNQ0
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ABCG2(9429) ; mouse ... Abcg2(26357)

詳細

詳細

Anti-Breast Cancer Resistance Protein is developed in rabbit using as immunogen a synthetic peptide of human breast cancer resistance protein (BCRP). BCRP, also designated ABCG2, ABCP, placenta specific ATP-binding transporter and mitoxantrone-resistance protein (MXR), is a member of the ABCG subfamily of the large ATP binding cassette (ABC) transporter family of transmembrane proteins. BCRP is a half-transporter, with a single ATP binding cassette and transmembrane region. BCRP is normally expressed in human placental syncytiotrophoblasts, mammary ducts and lobules, endothelial cells and stem cells of different tissues.

免疫原

ヒト乳癌耐性タンパク質(BCRP)のアミノ酸残基150-167に相当する合成ペプチド(C末端システイン付加)のKLH結合体。

アプリケーション

Anti-Breast Cancer Resistance Protein antibody produced in rabbit has been used in:

• western blotting
• immunocytochemistry
• immunohistochemistry

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生物化学的／生理学的作用

Up regulation of breast cancer resistance protein (BCRP) expression may be found in vivo and in vitro in both drugs treated and untreated tumors of different types. Breast cancer resistance protein transports various xenobiotics to the extracellular space through a process energized by ATP hydrolysis. In addition, to its role in protecting cells and tissues against xenobiotics especially in the intestine, liver, placenta and the blood-brain barrier, BCRP appears to be involved in hypoxic defense mechanisms and the protection and regulation of stem cells.

物理的形状

0.01 M PBS溶液(15 mM アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable