C1172

ML-9

≥99% (TLC), powder

• 別名: 1-(5-クロロナフタレン-1-スルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン 塩酸塩
• 化学式: C₁₅H₁₇N₂O₂SCl · HCl
• CAS番号: 105637-50-1
• 分子量: 361.29
• MDL番号: MFCD00065525
• UNSPSCコード: 12352202
• PubChem Substance ID: 24278297
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• アッセイ: ≥99% (TLC)
• フォーム: powder
• 色: white
• 溶解性: ethanol: 10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI Key: ZNRYCIVTNLZOGI-UHFFFAOYSA-N
• 遺伝子情報: human ... SLC2A1(6513) , SLC2A4(6517)

詳細

アプリケーション

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

生物化学的／生理学的作用

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca₂⁺ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

特徴および利点

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)