D2178

モノクローナル抗細胞死関連プロテインキナーゼ抗体 マウス宿主抗体

clone DAPK-55, ascites fluid

• 別名: 抗DAPキナーゼ抗体
• MDL番号: MFCD00282220
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ARR; IP; WB
• クローン: DAPK-55, monoclonal
• 化学種の反応性: human, monkey
• citations: 22
• テクニック: immunoprecipitation (IP): suitable; microarray: suitable; western blot: 1:250 using COS-7 cell extract

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: primary antibodies
• クローン: DAPK-55, monoclonal
• 分子量: antigen 160 kDa
• 含みます: 15 mM sodium azide
• 化学種の反応性: human, monkey
• テクニック: immunoprecipitation (IP): suitable; microarray: suitable; western blot: 1:250 using COS-7 cell extract
• アイソタイプ: IgG1
• UniProtアクセッション番号: P51397
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DAP(1611)

詳細

詳細

Monoclonal Anti-Death Associated Protein (DAP) Kinase (mouse IgG1 isotype) is derived from the DAPK-55 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Death-associated protein 1 (DAP1) gene is mapped to human chromosome 9q34.1. It belongs to the DAP family.

The gene is widely expressed in many tissues of embryonic and adult origin and gives rise to a single 6.3 Kb mRNA transcript. The protein consists of 1423 amino acids (160 kDa) and belongs to a family of calmodulin-dependent protein kinases. It contains 8 ankyrin repeats and 2 potential P-loop motifs apart from the kinase domain and the calmodulin regulatory domain.

免疫原

バクテリアで発現させたリコンビナントヒトDAPキナ-ゼ。

アプリケーション

Monoclonal Anti-Death Associated Protein Kinase antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

生物化学的／生理学的作用

DAP-kinase is a novel, structurally unique, human serine/threonine kinase identified as a positive mediator of interferon-γ-induced programmed cell death. It has an intrinsic kinase activity towards itself that is regulated by calmodulin and calcium.

Death-associated protein 1 (DAP1) participates in the regulation of cell growth and death including that of cancer cells. DAP-kinase has an intrinsic kinase activity towards itself that is regulated by calmodulin and calcium.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable