E9531

エバスチン

≥98% (HPLC), solid

• 別名: 1-[4-(1,1-ジメチルエチル)フェニル]-4-[4-(ジフェニルメトキシ)-1-ピペリジニル]-1-ブタノン
• 実験式（ヒル表記法）: C₃₂H₃₉NO₂
• CAS番号: 90729-43-4
• 分子量: 469.66
• MDL番号: MFCD00865661
• UNSPSCコード: 12352200
• PubChem Substance ID: 329799086
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: white
• 溶解性: DMSO: >10 mg/mL; H₂O: insoluble
• 保管温度: room temp
• SMILES記法: CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
• InChI: 1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
• InChI Key: MJJALKDDGIKVBE-UHFFFAOYSA-N

詳細

詳細

Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.

アプリケーション

Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.

生物化学的／生理学的作用

Ebastine is a non-sedating histamine H₁ receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.

特徴および利点

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)