F3922

抗線維芽細胞増殖因子受容体3, 細胞外 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗FGFR-3抗体
• MDL番号: MFCD01633348
• UNSPSCコード: 51111800
• NACRES: NA.41
• 結合体: unconjugated
• application: IHC (p); WB
• クローン: polyclonal
• 化学種の反応性: human
• citations: 4
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections; western blot: 1:500 using extract of FGFR-3 transfected cells

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~120 kDa
• 化学種の反応性: human
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections; western blot: 1:500 using extract of FGFR-3 transfected cells
• UniProtアクセッション番号: P22607
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FGFR3(2261)

詳細

詳細

FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.

免疫原

ヒト繊維芽細胞増殖因子レセプタ-3の細胞外領域のアミノ酸359-372に相当する合成ペプチド。

アプリケーション

Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:

• immunoblotting
• immunohistochemistry
• immunoprecipitation

生物化学的／生理学的作用

Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein.

物理的形状

0.01M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。

調製ノート

ペプチド-アガロ-スカラムによるアフィニティ-精製で分離しています。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable