F6771

Fumagillin

from Aspergillus sp. (Aspergillus fumigatus), ≥90% (HPLC), powder, MetAP2 inhibitor

• 別名: Fugillin
• 実験式（ヒル表記法）: C₂₆H₃₄O₇
• CAS番号: 23110-15-8
• 分子量: 458.54
• EC Number: 245-433-8
• MDL番号: MFCD03990453
• UNSPSCコード: 12352200
• PubChem Substance ID: 24894920
• NACRES: NA.77

特性

• 製品名: フマギリン Aspergillus fumigatus由来, ≥90%, powder
• 由来生物: Aspergillus sp. (Aspergillus fumigatus)
• 品質水準: 200
• アッセイ: ≥90%
• フォーム: powder
• 色: white
• mp: 197-198 °C
• 溶解性: ethanol: 1 mg/mL
• 抗生物質活性スペクトル: fungi
• 作用機序: DNA synthesis | interferes
• 保管温度: −20°C
• SMILES記法: COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
• InChI: 1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
• InChI Key: NGGMYCMLYOUNGM-HCNIIHBUSA-N

詳細

詳細

Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.

アプリケーション

Fumagillin from Aspergillus fumigatus has been used:

• in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
• to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
• as a positive control in in vitro and ex vivo studies

生物化学的／生理学的作用

メチオニンアミノペプチダ-ゼ-2 (MetAP-2) のインヒビタ-で、内皮細胞増殖と血管新生を阻害します。

Fumagillin is known to be effective against microsporidian fungal infections.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves