I6760

モノクロナール抗ヒトIgG (Fc特異的) マウス宿主抗体

clone HP-6017, ascites fluid

• 別名: モノクロナール抗ヒトIgG (Fc特異的)
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: secondary antibodies
• クローン: HP-6017, monoclonal
• 含みます: 15 mM sodium azide
• 化学種の反応性: rabbit, sheep, horse (IgG), goat, human
• テクニック: indirect ELISA: 1:3,000
• アイソタイプ: IgG2a
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified

詳細

詳細

Monoclonal Anti-Human IgG (mouse IgG2a isotype) is derived from the hybridoma1 produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulins (Igs) belongs immunoglobulin super-family and have two heavy (H) and two light (L) chain, held together by disulphide linkages. The four classes of IgG can be IgG1, IgG2, IgG3 and IgG4. Each light chain comprises one variable N-terminal region and a constant C-terminal region. Heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal region.

特異性

この抗体は、ヒトIgGのFc部分に特異的であり、すべてのヒトIgGサブクラスに共通のエピトープを認識します。この抗体は、IUIS/WHO研究でFc特異的試薬として採用されました。

アプリケーション

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse has been used in:

• enzyme linked immunosorbent assay (ELISA)
• imprint immunofixation (IIF)
• immunofluorometric assay (IFMA)
• hemagglutination (HA)
• hemagglutination inhibition (HAI)
• particle counting immunoassay(PACIA)

生物化学的／生理学的作用

Although the antibody site is located in the terminal end of human IgG (part of the Fab fragment), the Fc portion has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess a "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of human IgG.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable