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Merck

L7016

Sigma-Aldrich

Monoclonal Anti-LDH (H-Subunit) antibody produced in mouse

clone HH-17, ascites fluid

別名:

Anti-Lactic Dehydrogenase (H-Subunit)

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About This Item

MDL番号:
UNSPSCコード:
12352203
NACRES:
NA.46

由来生物

mouse

品質水準

結合体

unconjugated

抗体製品の状態

ascites fluid

抗体製品タイプ

primary antibodies

クローン

HH-17, monoclonal

含みます

15 mM sodium azide

化学種の反応性

human

テクニック

indirect ELISA: 1:5,000

アイソタイプ

IgG1

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... LDHB(3945)

詳細

Lactate dehydrogenase (LDH) is an NADH-dependent enzyme that catalyzes the reversible conversion of pyruvate to lactate. Human LDH has two known isoforms, the H isoform which is primarily found in heart tissues and the M isoform that occurs mostly in muscle tissues.
Monoclonal Anti-LDH (H-Subunit) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

免疫原

Human LDH-H4 isoenzyme

アプリケーション

Monoclonal Anti-LDH (H-Subunit) antibody produced in mouse has been used in:
  • immunoblotting†
  • immunohistochemistry
  • microscopy

生物化学的/生理学的作用

Lactate dehydrogenase (LDH) is an NADH-dependent enzyme that catalyzes the reversible conversion of pyruvate to lactate.
Lactate dehydrogenase (LDH) is an NADH-dependent enzyme that catalyzes the reversible conversion of pyruvate to lactate. Human LDH has two known isoforms, the H isoform which is primarily found in heart tissues and the M isoform that occurs mostly in muscle tissues . Ratio of LDH isozymes H4 and H3M can be used as diagnostic and prognostic markers of myocardial infarction . Monoclonal Anti-Human Lactate Dehydrogenase is specific for human LDH isozymes containing the H-subunit. The antibody does not cross-react with the M4 isozyme.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

12 - Non Combustible Liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

L7016-.1ML:
L7016-VAR:
L7016-BULK:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

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文書ライブラリにアクセスする

Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity
Dyer PDR, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 220, 316-328 (2015)
Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise
Philp A, et al.
The Journal of Biological Chemistry, 286(35), 30561-30570 (2011)
Andrei Seluanov et al.
DNA repair, 6(12), 1740-1748 (2007-08-10)
Aging is associated with accumulation of genomic rearrangements consistent with aberrant repair of DNA breaks. We have shown previously that DNA repair by non-homologous end joining (NHEJ) becomes less efficient and more error-prone in senescent cells. Here, we show that
NAD-dependent lactate dehydrogenase catalyses the first step in respiratory utilization of lactate by Lactococcus lactis
Zhao R, et al.
FEBS Open Bio, 3, 379-386 (2013)
Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer
Leiblich A, et al.
Oncogene, 25(20), 2953-2953 (2006)

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