S0383

スルファメータ

• 別名: 5-メトキシスルファジアジン, N¹-(5-メトキシピリミジン-2-イル)スルファニルアミド
• 実験式（ヒル表記法）: C₁₁H₁₂N₄O₃S
• CAS番号: 651-06-9
• 分子量: 280.30
• Beilstein: 621130
• EC Number: 211-480-8
• MDL番号: MFCD00006067
• UNSPSCコード: 51283913
• PubChem Substance ID: 24899422
• NACRES: NA.85

特性

• 形状: powder
• 品質水準: 200
• 保管条件: (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.)
• 色: white to faint yellow
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; parasites
• 作用機序: enzyme | inhibits
• 保管温度: 2-8°C
• SMILES記法: COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
• InChI: 1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
• InChI Key: GPTONYMQFTZPKC-UHFFFAOYSA-N

詳細

詳細

Chemical structure: sulfonamide

アプリケーション

Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.

生物化学的／生理学的作用

Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

その他情報

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves