S9263

スワインソニン

solid, ≥99% (HPLC)

• 別名: (1S,2R,8R,8aR)-1,2,8-オクタヒドロインドリジジントリオール
• 実験式（ヒル表記法）: C₈H₁₅NO₃
• CAS番号: 72741-87-8
• 分子量: 173.21
• Beilstein: 4175740
• MDL番号: MFCD00017554
• UNSPSCコード: 12352210
• PubChem Substance ID: 24899832
• NACRES: NA.32

特性

• product name: スワインソニン, synthetic
• 由来生物: synthetic
• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• 形状: solid
• 溶解性: methanol: 5 mg/mL, clear, colorless to light yellow
• 保管温度: −20°C
• SMILES記法: O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12
• InChI: 1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1
• InChI Key: FXUAIOOAOAVCGD-DCDLSZRSSA-N

詳細

詳細

Swainsonine is produced by endophytes, plant and insect pathogens. It is synthesized from the pipecolic acid and mevalonic acid. Swainsonine is a water-soluble indole alkaloid.

アプリケーション

Swainsonine has been used:

• to test its effect on neural stem cell proliferation
• to inhibit α-mannosidase in TC-1 tumor cells
• to inhibit β1,6-branching synthesis in hepatocellular carcinoma (HCC) cells

スワインソニンは、様々なα-マンノシダ-ゼ、特にα-マンノシダ-ゼIIの強力なインヒビタ-です。糖タンパク質プロセシングを阻害し、免疫調節因子としても作用します。

生物化学的／生理学的作用

Swainsonine is an inhibitor of α-mannosidase in endoplasmic reticulum and Golgi apparatus. It also activates the natural killer cells. Swainsonine elicits neurologic toxicity and its exposure impairs learning and memory resulting in cognitive deficit. It inhibits hepatocellular carcinoma and sensitizes them to respond to anti-cancer drug paclitaxel.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves