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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous glycerol solution
分子量
17 kDa
化学種の反応性
human, mouse, rat
濃度
~1 mg/mL
テクニック
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PMP22(5376)
詳細
Anti-PMP22 Antibody detects endogenous levels of total PMP22 protein.
Peripheral myelin protein 22 (PMP22), also called as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein, encoded by the gene mapped to human chromosome 17p12–13. PMP22 is highly expressed in myelin-forming Schwann cells of peripheral nerves.
免疫原
The antiserum was produced against synthesized peptide derived from human PMP22.
Immunogen Range: 111-160
Immunogen Range: 111-160
アプリケーション
Anti-PMP22 antibody produced in rabbit has been used in:
- immunofluorescence
- western blotting
- immunohistochemistry
Anti-PMP22, C-Terminal antibody produced in rabbit has been used in immunofluorescence analysis.
生物化学的／生理学的作用
Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during development of peripheral nerve, cell–cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Biological function of PMP22, might include formation and or maintenance of intercellular junctions and possibly of tight junctions (TJs). Aberrations, duplications or mutations in PMP22 gene lead to majority of heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. PMP2, might be involved in regulation of Schwann cell proliferation and differentiation.5 Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML). PMP22 might, thus, act as a therapeutic target for the treatment of CML.
特徴および利点
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物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4502217-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Martial Caillaud et al.
Neuropharmacology, 139, 98-116 (2018-07-19)
Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the
Hui Liu et al.
Oncology research, 22(5-6), 259-265 (2015-12-03)
We aimed to explore the underlying mechanism of peripheral myelin protein 22 (PMP22) in the development of chronic myeloid leukemia (CML). The level of PMP22 expression in CD34(+) cells isolated from CML patients' bone marrow samples (BMMCs) and peripheral blood
Zeina Msheik et al.
Neural regeneration research, 18(6), 1354-1363 (2022-12-02)
The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models: the sciatic nerve crush and the Charcot-Marie-Tooth-1A disease. In this study, we sought to highlight and compare the protein signature of these
Doris Krauter et al.
EMBO molecular medicine, 16(3), 616-640 (2024-02-22)
Haplo-insufficiency of the gene encoding the myelin protein PMP22 leads to focal myelin overgrowth in the peripheral nervous system and hereditary neuropathy with liability to pressure palsies (HNPP). Conversely, duplication of PMP22 causes Charcot-Marie-Tooth disease type 1A (CMT1A), characterized by
K Adlkofer et al.
Nature genetics, 11(3), 274-280 (1995-11-01)
Peripheral myelin protein PMP22 has been suggested to have a role in peripheral nerve myelination and cell proliferation. Defects at the PMP22 locus are associated with peripheral neuropathies such as Charcot-Marie-Tooth disease type 1A. We now demonstrate that mice devoid
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