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由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
MEM-61, monoclonal
形状
buffered aqueous solution
化学種の反応性
human
濃度
1 mg/mL
テクニック
flow cytometry: suitable
アイソタイプ
IgG1
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CD9(928)
詳細
CD9 (cluster of differentiation 9) is a human cell surface antigen. CD9 gene contains 8 exons extending over a length of 20kb on genomic DNA.The gene is mapped to human chromosome 2q12-pter. The encoded protein has a molecular weight of 24kDa and is expressed mainly on B-lineage-derived acute lymphoblastic leukemia cells and developing B lymphocytes.The protein is also present in blood platelets, neuroblastoma cell lines, normal and transformed epithelia, peripheral glia and neurons. CD9 antigen belongs to the transmembrane 4 superfamily (TM4SF) and is characterized with two external loops and four hydrophobic domains of membrane-spanning length.
免疫原
Pre-B cell line NALM-6
アプリケーション
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生物化学的／生理学的作用
Members of transmembrane 4 superfamily (TM4SF) including CD9 (cluster of differentiation 9) plays a vital role in cell proliferation, activation, motility and tumor cell metastasis. CD9 facilitates platelet activation and aggregation. The encoded protein also plays a major role in the amplification of a motorgenic signal in B cells includingβ1 integrins and the activation of protein tyrosine kinases. CD9 interacts with GM3 and downregulates tumor cell motility. CD9 and CD81 stimulate muscle cell fusion and aids in myotube maintenance.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
PBS（pH 7.4、15 mM アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4700092-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Platelet activation by immobilized monoclonal antibody: evidence for a CD9 proximal signal.
Griffith L
Blood, 78, 1753-1759 (1991)
Fernanda G Kugeratski et al.
Nature cell biology, 23(6), 631-641 (2021-06-11)
Exosomes are extracellular vesicles derived from the endosomal compartment that are potentially involved in intercellular communication. Here, we found that frequently used biomarkers of exosomes are heterogeneous, and do not exhibit universal utility across different cell types. To uncover ubiquitous
Yibei Dai et al.
Frontiers in oncology, 11, 777684-777684 (2021-12-14)
Prostate cancer (PCa) is one of the most frequently diagnosed cancers and the leading cause of cancer death in males worldwide. Although prostate-specific antigen (PSA) screening has considerably improved the detection of PCa, it has also led to a dramatic
Mayela Mendt et al.
JCI insight, 3(8) (2018-04-20)
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells. Here, we report on a bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP)
Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation.
Shaw AR
The Journal of Biological Chemistry, 270, 24092-24099 (1995)
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