SMB00704

Lipopolysaccharides from Proteus mirabilis

purified by phenol extraction

• 別名: LPS
• EC Number: 297-473-0
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• 由来生物: bacterial (Proteus mirabilis)
• 品質水準: 200
• フォーム: lyophilized powder
• 精製方法: phenol extraction
• 不純物: <3.00% protein (Lowry-TCA)
• 色: white to faint yellow
• 溶解性: water: 0.90-1.10 mg/mL, slightly hazy to hazy, colorless to light yellow
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

Lipopolysaccharides (LPS′s) are complex glycolipids that are characteristic components of the cell wall of Gram-negative bacteria. They consist of a lipid A moiety linked to an antigenic O-polysaccharide.
Proteus mirabilis is a Gram-negative facultative anaerobic rod-shaped bacterium. Bacteria of the genus Proteus of the family Enterobacteriaceae are opportunistic human pathogens responsible for wound and burn infections as well as skin, eye, ear, nose, throat, urinary tract, and gastrointestinal infections and bacteremias.

アプリケーション

• Lipopolysaccharide structure modulates cationic biocide susceptibility and crystalline biofilm formation in Proteus mirabilis.: The study explores how variations in lipopolysaccharide structure affect the susceptibility of Proteus mirabilis to biocides and its ability to form crystalline biofilms, informing strategies to combat biofilm-associated infections (Clarke et al., 2023).

生物化学的／生理学的作用

Lipopolysaccharide (LPS) and its lipid A moiety stimulate cells of the innate immune system by the toll-like receptor 4 (TLR4), a member of the toll-like receptor protein family, which recognizes common pathogen-associated molecular patterns (PAMPs). Lipid A plays a role in the biological properties attributed to endotoxic LPS. LPS is a highly immunogenic antigen that has the ability to enhance immune responses.The outer-membrane lipopolysaccharide is considered an important virulence factor of Proteus. It has been suggested that the immunological response against P. mirabilis, LPS might play a role in rheumatoid arthritis. A possible correlation between the abundance of P. mirabilis in the intestine and obesity was suggested recently. The purified LPS from P. mirabilis OXK is used in the Weil-Felix test for the diagnosis of rickettsiosis (scrub typhus) caused by the bacterium Orientia (Rickettsia) tsutsugamushi.

調製ノート

Soluble in water and cell culture medium DMEM (1 mg/mL) yielding a clear to slightly hazy solution.

その他情報

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable