SMB01050

Licochalcone B

≥85% (LC/MS-ELSD)

• 別名: (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, 3,4,4′-trihydroxy-2-methoxychalcone
• 実験式（ヒル表記法）: C₁₆H₁₄O₅
• CAS番号: 58749-23-8
• 分子量: 286.28
• MDL番号: MFCD20527294
• UNSPSCコード: 12352205
• NACRES: NA.25

特性

• 由来生物: plant
• アッセイ: ≥85% (LC/MS-ELSD)
• 形状: solid
• 分子量: 286.28
• 溶解性: water: slightly soluble
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: −20°C
• InChI: 1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
• InChI Key: DRDRYGIIYOPBBZ-XBXARRHUSA-N

詳細

詳細

Licochalcone B is a prenylated flavonoid classified within the group of retrochalcones. This bioactive natural compound is commonly sourced from Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, and G. aspera) plants. Existing research indicates that this plant-derived metabolite possesses a wide array of biological activities, including antibacterial, cardioprotective, anticancer, antioxidant, antiapoptotic, neuroprotective and anti-inflammatory properties.

アプリケーション

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生物化学的／生理学的作用

According to the existing research, Licochalcone B exerts its effects through multiple pathways, making it a versatile candidate for various therapeutic applications. It effectively combats inflammation by inhibiting NF-κB activation induced by LPS, leading to reduced production of NO, TNFα, and MCP-1. For bladder cancer, Licochalcone B demonstrates its potential by inducing S phase arrest, modulating cell cycle-related proteins, suppressing anti-apoptotic factors, and activating caspase-3. These actions collectively limit tumor growth in vivo, suggesting its utility in both bladder cancer therapy and prevention. Furthermore, Licochalcone B showcases robust antioxidant capabilities, successfully mitigating lipid peroxidation and lowering ROS production. It also exhibits anti-inflammatory properties by decreasing the release of NO, IL-6, and PGE2 in response to LPS. Furthermore, Licochalcone B emerges as a promising candidate for Alzheimer′s disease treatment, effectively preventing Aβ42 aggregation, chelating metal ions, and providing neuroprotection.

特徴および利点

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable