SML0762

Enzastaurin

≥98% (HPLC)

• 別名: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione, D04014, LY-317615, LY317615
• 実験式（ヒル表記法）: C₃₂H₂₉N₅O₂
• CAS番号: 170364-57-5
• 分子量: 515.60
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: , light orange to dark orange-red
• 溶解性: DMSO: 10 mg/mL, clear (warmed)
• 保管温度: −20°C
• SMILES記法: N1C(=O)C(=C(C1=O)c6c7c([n](c6)C)cccc7)c2c3c([n](c2)C4CCN(CC4)Cc5ncccc5)cccc3
• InChI: 1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
• InChI Key: AXRCEOKUDYDWLF-UHFFFAOYSA-N

詳細

アプリケーション

Enzastaurin has been used in splicing analysis to study its effects on splicing of a mutated exon.

生物化学的／生理学的作用

Enzastaurin is a potent and PKCβ preferring inhibitor. Also, Enzastaurin inhibits AKT and GSK3β. Enzastaurin acts as anti-angiogenic and antineoplastic agent.

It is an orally administered drug. It can induce apoptosis, inhibit angiogenesis and proliferation of cells. Enzastaurin can be used for the treatment of haematological cancers.

特徴および利点

This compound is featured on the GSK-3, PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H413
• 注意書き: P273 - P301 + P312 + P330
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Chronic 4
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable