SML1180

WWL229

≥98% (HPLC)

• 別名: 2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
• 実験式（ヒル表記法）: C₁₆H₂₂N₂O₅
• CAS番号: 1338575-28-2
• 分子量: 322.36
• UNSPSCコード: 12161501
• PubChem Substance ID: 329825704
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: oil
• 色: colorless to light yellow
• 保管温度: 2-8°C
• SMILES記法: O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
• InChI: 1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
• InChI Key: XVBRVSAGMWRVCK-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC₅₀ of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable