SML1504

Tegaserod maleate

≥98% (HPLC)

• 別名: 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
• 実験式（ヒル表記法）: C₁₆H₂₃N₅O · C₄H₄O₄
• CAS番号: 189188-57-6
• 分子量: 417.46
• MDL番号: MFCD09028009
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825925
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: N=C(NCCCCC)N/N=C/C1=CNC2=C1C=C(OC)C=C2.OC(/C=C\C(O)=O)=O
• InChI: 1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-
• InChI Key: CPDDZSSEAVLMRY-FEQFWAPWSA-N
• 遺伝子情報: human ... HTR4(3360)

詳細

アプリケーション

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

生物化学的／生理学的作用

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.

Tegaserod is a potent full agonist at serotonin 5-HT4 receptors with an EC₅₀ of 7 nM.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable