SML2008

Tiotropium bromide monohydrate

≥98% (HPLC)

• 別名: (1α, 2β, 4 β, 5α, 7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate, 3-Oxa-9-azoniatricyclo[3.3.1.02,4]?nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, hydrate (1:1:1), (1α,2β,4β,5α,7β), 6β,7β-epoxy-3β-hydroxy-8-methyl-1αH,5αH-tropanium bromide monohydrate, di-2-thienylglycolate
• 実験式（ヒル表記法）: C₁₉H₂₂BrNO₄S₂ · H₂O
• CAS番号: 411207-31-3
• 分子量: 490.43
• MDL番号: MFCD23704176
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: [H]O[H].O=C(C(C1=C([H])C([H])=C([H])S1)(O[H])C2=C([H])C([H])=C([H])S2)O[C@@]3([H])C([H])([H])[C@@]4([H])[C@@]5([H])[C@@](O5)([H])[C@](C3([H])[H])([H])[N+]4(C([H])([H])[H])C([H])([H])[H].[Br-]
• InChI: 1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p-1/t11?,12-,13+,16?,17?;;
• InChI Key: MQLXPRBEAHBZTK-YQMLGFMRSA-M

詳細

アプリケーション

Tiotropium bromide monohydrate may be used as a long-acting muscarinic receptor antagonist (LAMA) in a comparative study to explore its efficacy in the downregulation of the cough reflex in rabbits.

生物化学的／生理学的作用

Tiotropium Bromide is an anticholinergic bronchodilator. It is considered a long-acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for chronic obstructive pulmonary disease (COPD) and asthma.

Tiotropium bromide exhibits more beneficial effects on pulmonary function than other anticholinergic and β-2 adrenergic agents. Tiotropium can prevent the proliferation of fibroblasts and myofibroblasts induced by acetylcholine. It can block human monocyte chemotaxis.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable