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由来生物
human
リコンビナント
expressed in E. coli
アッセイ
≥90% (SDS-PAGE)
フォーム
aqueous solution
分子量
14.8 kDa
包装
pkg of 1 mg
保管条件
avoid repeated freeze/thaw cycles
濃度
1.2 mg/mL
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
human ... HIST2H2AC(8338)
詳細
Histone cluster 2 H2A family member c (HIST2H2AC) is located on human chromosome 1q21. It is usually present in undifferentiated/proliferating cells. This canonical histone isoform has a protruding tail at both the N- and C-termini.
Histones make up the nucleosome, which is the fundamental unit of the chromatin. Each nucleosome consists of 146 base pairs of DNA which is wrapped around an octamer of four core histones H2A, H2B, H3 and H4. Histone cluster 2 H2A family member c (HIST2H2AC) has many variants. Human Histone 2A (GenBank Accession No. NM_033445) amino acids 2-130 (end) with N-terminal His-tag, MW = 14.8 kDa, expressed in an E. coli expression system.
生物化学的／生理学的作用
Histone cluster 2 H2A family member c (HIST2H2AC) has a role in maintaining the structure of the chromatin.
Histone cluster 2 H2A family member c (HIST2H2AC) participates in multiple epigenetic regulations and carcinogenesis. It also participates in embryonic stem (ES) cell biology and regulates the expression of genes. It modulates proliferation and epithelial-mesenchymal transition in mammary epithelial and breast cancer cells. Hist2h2ac also controls epithelial differentiation.
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP0406-1MG:
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試験成績書（COA）
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Wenlai Zhou et al.
The international journal of biochemistry & cell biology, 41(1), 12-15 (2008-10-22)
The precise molecular strategies that coordinate patterns of transcriptional response to specific signals is central for understanding normal development and disease. Precise control of transcriptional programs underlying metazoan development is modulated by enzymatically active coregulatory complexes, coupled with epigenetic strategies.
The histone H2A isoform Hist2h2ac is a novel regulator of proliferation and epithelial-mesenchymal transition in mammary epithelial and in breast cancer cells
Monteiro FL, et al.
Cancer Letters, 396, 42-52 (2017)
Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects.
Karaczyn AA
Annals of Clinical and Laboratory Science, 39(3), 251-262 (2009)
Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome.
Ishibashi T
Biochemistry, 48(22), 5007-5017 (2009)
Mary Ann Osley
Briefings in functional genomics & proteomics, 5(3), 179-189 (2006-06-15)
Histone ubiquitylation has emerged as an important chromatin modification with roles in transcription and trans-histone methylation. In the past several years, there has been dramatic progress in the identification of factors that control ubiquitin attachment to the core histones H2A
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