T1815

Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody produced in mouse

clone 22221, purified immunoglobulin, lyophilized powder

• 別名: Anti-TNFRSF1B
• MDL番号: MFCD01633483
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ARR; ICC; Neutral
• クローン: 22221, monoclonal
• 化学種の反応性: human
• citations: 5
• テクニック: immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood lymphocytes; microarray: suitable; neutralization: suitable

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 22221, monoclonal
• フォーム: lyophilized powder
• 化学種の反応性: human
• テクニック: immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood lymphocytes; microarray: suitable; neutralization: suitable
• アイソタイプ: IgG2a
• UniProtアクセッション番号: P01375
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TNF(7124)

詳細

詳細

The tumor necrosis factor super family (TNFSF) consists of at least 19 transmembrane proteins with soluble forms that are generated by proteolysis. The biological effects of TNF are mediated by either type I or type II receptors. Type I receptors that are ubiquitously present on all cells whereas type II receptors are expressed only on cells of immune system (monocytes, macrophages, Langerhans cells) and endothelial cells. Receptors of TNFSF such as TNFR I and Fas have their own death domains that activate the apoptosis. Other receptors such as TNFR II do not have death domains and utilize TNF associated factors (TRAFs) to activate intracellular signaling. TNFR II activates NF-κB pathway via the activation of NIK. Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody recognizes human TNFR II.

特異性

The antibody neutralizes the biological effect of recombinant human TNF RII. It does not neutralize or cross-react with TNF RI.

免疫原

recombinant human tumor necrosis factor receptor II, expressed in Escherichia coli.

アプリケーション

Anti-Tumor Necrosis Factor Receptor II antibody may be used for immunocytochemistry at a working concentration of 8-25 μg/ml using human peripheral blood lymphocytes. The antibody is suitable for neutralization assays and protein microarray. The antibody was used for flow cytometry using human CD8 T cells.

物理的形状

凍結乾燥品(PBS溶液, 5%トレハロース含有, 0.2 μmフィルター滅菌済み)。

調製ノート

Purified using protein A

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable