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About This Item
結合体:
unconjugated
application:
WB
クローン:
polyclonal
化学種の反応性:
mammals, human
citations:
22
テクニック:
western blot: 1:1,000 using human dorsal raphe nucleus
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製品名
抗トリプトファンヒドロキシラーゼ抗体 ヒツジ宿主抗体, affinity isolated antibody, buffered aqueous glycerol solution
由来生物
sheep
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous glycerol solution
使用法
sufficient for 10 blots
化学種の反応性
mammals, human
テクニック
western blot: 1:1,000 using human dorsal raphe nucleus
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... TPH1(7166)
mouse ... Tph1(21990)
rat ... Tph1(24848)
詳細
The tryptophan hydroxylase 1 (TPH1) gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. TPH1, is a 444 amino acid protein expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
Tryptophan Hydroxylase (TPH) is a member of the aromatic amino acid hydroxylases (AAAH) family.
免疫原
E. coliから封入体として分離され、SDS-PAGEで精製された、組み換えウサギトリプトファンヒドロキシラ-ゼ。
アプリケーション
Anti-Tryptophan Hydroxylase antibody produced in sheep has been used in:
- immunocytochemistry
- immunohistochemistry
- immunofluorescence
- immunoperoxidase staining
生物化学的／生理学的作用
The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.
物理的形状
150mM NaCl, 10mM HEPES溶液(pH 7.5, 100μg/mL BSA, 50%グリセロ-ル含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T8575-1VL:
T8575-BULK:
T8575-VAR:
T8575-1VL-PW:
Mahsa Moaddab et al.
Scientific reports, 10(1), 18035-18035 (2020-10-24)
Early adolescent adversity increases adult risk for anxiety disorders. The ventrolateral periaqueductal gray (vlPAG) and neighboring dorsal raphe (DR) are integral to threat prediction, and are responsive to acute stressors. Here, we tested the hypothesis that early adolescent adversity reshapes
Matthew W Hale et al.
Experimental neurology, 224(1), 271-281 (2010-04-13)
Serotonin plays an important role in the regulation of anxiety states and physiological responses to aversive stimuli. Intracerebroventricular (i.c.v.) injection of the stress- and anxiety-related neuropeptide urocortin 2 (Ucn 2) increases c-Fos expression in serotonergic neurons in the dorsal (DRD)
GABAergic neurons in the dorsal raphe nucleus that express 5-HT3A receptors participate in responses to stress hormones
Li X, et al.
Neuroscience, 9(7), e101420-e101420 (2020)
Leah R Brooks et al.
Behavioural brain research, 264, 74-81 (2014-02-12)
Serotonergic neurons in the dorsal raphe nucleus (DR) are organized in anatomically distinct subregions that form connections with specific brain structures to modulate diverse behaviors, including anxiety-like behavior. It is unclear if the functional heterogeneity of these neurons is coupled
Kristina M Wright et al.
eLife, 8 (2019-03-08)
Faced with potential harm, individuals must estimate the probability of threat and initiate an appropriate fear response. In the prevailing view, threat probability estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fear output. A straightforward prediction is
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