추천 제품
product name
(+)-S-Trityl-L-cysteine, 97%
Quality Level
분석
97%
광학 활성
[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
반응 적합성
reaction type: solution phase peptide synthesis
mp
182-183 °C (dec.) (lit.)
응용 분야
peptide synthesis
SMILES string
N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O
InChI
1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
InChI key
DLMYFMLKORXJPO-FQEVSTJZSA-N
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애플리케이션
(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.
이미 열람한 고객
Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but
Proteomics, 8(2), 289-300 (2008-01-11)
Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests
Total synthesis of didmolamides A and B
Tetrahedron Letters, 46(15), 2567-2570 (2005)
Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein
European Journal of Medicinal Chemistry, 215, 113288-113288 (2021)
Synthesis and electrochemical studies of disubstituted ferrocene/dipeptide conjugates with sulfur-containing side chains
Tetrahedron, 66(30), 5653-5659 (2010)
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