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Merck
모든 사진(1)

주요 문서

164739

Sigma-Aldrich

(+)-S-Trityl-L-cysteine

97%, for peptide synthesis

동의어(들):

S-Trityl-L-cysteine

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About This Item

Linear Formula:
(C6H5)3CSCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
363.47
Beilstein:
2339626
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22

product name

(+)-S-Trityl-L-cysteine, 97%

Quality Level

분석

97%

광학 활성

[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl

반응 적합성

reaction type: solution phase peptide synthesis

mp

182-183 °C (dec.) (lit.)

응용 분야

peptide synthesis

SMILES string

N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O

InChI

1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1

InChI key

DLMYFMLKORXJPO-FQEVSTJZSA-N

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애플리케이션

(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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시험 성적서(COA)

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문서 라이브러리 방문

James A D Good et al.
Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but
Frank Kozielski et al.
Proteomics, 8(2), 289-300 (2008-01-11)
Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests
Total synthesis of didmolamides A and B
You Shu-Li and Kelly JW
Tetrahedron Letters, 46(15), 2567-2570 (2005)
Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein
Fukai R, et al.
European Journal of Medicinal Chemistry, 215, 113288-113288 (2021)
Synthesis and electrochemical studies of disubstituted ferrocene/dipeptide conjugates with sulfur-containing side chains
Scully CCG and Rutledge PJ
Tetrahedron, 66(30), 5653-5659 (2010)

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