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Merck
모든 사진(4)

주요 문서

318337

Sigma-Aldrich

Acridine Orange hydrochloride hydrate

≥98% (HPLC)

동의어(들):

3,6-Bis(dimethylamino)acridine hydrochloride

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About This Item

실험식(Hill 표기법):
C17H19N3 · HCl · xH2O
CAS Number:
Molecular Weight:
301.81 (anhydrous basis)
색상 지수 번호:
46005
Beilstein:
3734978
EC Number:
MDL number:
UNSPSC 코드:
12171500
PubChem Substance ID:
NACRES:
NA.47

Quality Level

분석

≥98% (HPLC)

형태

powder

기술

microbe id | staining: suitable

색상

orange

mp

284-287 °C (lit.)

solubility

H2O: 0.1%, clear, orange to red

λmax

492 nm

ε (흡광계수)

≥14,000 at 227-233 nm in water at 0.005 g/L
≥35000 at 265-271 nm in water at 0.005 g/L

응용 분야

diagnostic assay manufacturing
hematology
histology

저장 온도

room temp

SMILES string

Cl[H].[H]O[H].CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C

InChI

1S/C17H19N3.ClH.H2O/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;;/h5-11H,1-4H3;1H;1H2

InChI key

JUAAUEXLEKAEQC-UHFFFAOYSA-N

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애플리케이션

A rigorously purified zinc-free material suitable for use in flow cytometry.
Acridine Orange hydrochloride hydrate dye has been used:
  • to stain intracellular acidic vesicles.
  • to measure lysosomal membrane permeability (LMP).
  • or autophagy detection.
Fluorescent stain for nucleic acids in agarose and polyacrylamide gels. Has been used to study apoptosis in various cell culture and tissue models.

생화학적/생리학적 작용

Acridine Orange is a metachromatic dye which can stain DNA, RNA and acid glycosaminoglycans. At low concentrations, it intercalates into DNA and precipitates RNA. However, at high concentrations it denatures and precipitates both RNA and DNA. Acridine Orange is also used to analyze autophagy. It enters into acidic organelles in a pH-dependent manner. At neutral pH, acridine orange gives a green fluorescence and in acidic conditions, it accumulates in acidic organelles giving a bright red fluorescence.

추천 제품

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

픽토그램

Health hazard

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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